The role of computational cellular models in industrial bioprocesses: From genetic engineering to plant design
•Reviews mechanistic, statistical, and hybrid cellular modeling approaches.
•Links cellular models to strain, reactor, and plant-scale decisions.
•Shows why fitness to purpose in modeling matters more than model complexity or novelty.
•Highlights model tractability as a key barrier to multiscale integration and digital twins.
Citation
Garcia, S. (2026). The role of computational cellular models in industrial bioprocesses: From genetic engineering to plant design. Biotechnology Advances, 92, 108962. https://doi.org/10.1016/j.biotechadv.2026.108962
Authors from IE Research Datalab